DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection

Lead is a very toxic substance that causes metabolic disruption by mimicking the chemical profile of other important ions in the human body. The current technique of determining the presence of lead in drinkable water are simply too expensive to be implemented for large-scale real time monitoring. A...

Full description

Main Authors: Chee, L.H., Kumar, P., Kang, C.H., Burhanudin, Z.A.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.19991 /
Published: Institute of Electrical and Electronics Engineers Inc. 2017
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039949293&doi=10.1109%2fRSM.2017.8069165&partnerID=40&md5=a1de14776cf046e054ee2959aa3d18f3
http://eprints.utp.edu.my/19991/
Tags: Add Tag
No Tags, Be the first to tag this record!
id utp-eprints.19991
recordtype eprints
spelling utp-eprints.199912018-04-22T14:31:31Z DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection Chee, L.H. Kumar, P. Kang, C.H. Burhanudin, Z.A. Lead is a very toxic substance that causes metabolic disruption by mimicking the chemical profile of other important ions in the human body. The current technique of determining the presence of lead in drinkable water are simply too expensive to be implemented for large-scale real time monitoring. As an alternative, a sensor based on graphene field effect transistor is developed. The graphene layer itself is decorated with gold nanoparticle (AuNP) and it acts as a sensing medium while guanine-rich deoxyribonucleic acid (DNA) that is attached to the AuNP acts as a chemical probe. The guanine-rich DNA forms G-quadruplex when exposed to lead ions and thus changes the overall charge on the surface of the graphene. The changes can be observed via I-V measurement of the sensor. The fabricated sensors are capable of detecting lead ions even at 20 nM concentration. Such a sensor is scalable and can offer a cheap and effective option for monitoring the quality of water in real-time. © 2017 IEEE. Institute of Electrical and Electronics Engineers Inc. 2017 Article PeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039949293&doi=10.1109%2fRSM.2017.8069165&partnerID=40&md5=a1de14776cf046e054ee2959aa3d18f3 Chee, L.H. and Kumar, P. and Kang, C.H. and Burhanudin, Z.A. (2017) DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection. Proceedings of the 2017 IEEE Regional Symposium on Micro and Nanoelectronics, RSM 2017 . pp. 127-130. http://eprints.utp.edu.my/19991/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Lead is a very toxic substance that causes metabolic disruption by mimicking the chemical profile of other important ions in the human body. The current technique of determining the presence of lead in drinkable water are simply too expensive to be implemented for large-scale real time monitoring. As an alternative, a sensor based on graphene field effect transistor is developed. The graphene layer itself is decorated with gold nanoparticle (AuNP) and it acts as a sensing medium while guanine-rich deoxyribonucleic acid (DNA) that is attached to the AuNP acts as a chemical probe. The guanine-rich DNA forms G-quadruplex when exposed to lead ions and thus changes the overall charge on the surface of the graphene. The changes can be observed via I-V measurement of the sensor. The fabricated sensors are capable of detecting lead ions even at 20 nM concentration. Such a sensor is scalable and can offer a cheap and effective option for monitoring the quality of water in real-time. © 2017 IEEE.
format Article
author Chee, L.H.
Kumar, P.
Kang, C.H.
Burhanudin, Z.A.
spellingShingle Chee, L.H.
Kumar, P.
Kang, C.H.
Burhanudin, Z.A.
DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection
author_sort Chee, L.H.
title DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection
title_short DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection
title_full DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection
title_fullStr DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection
title_full_unstemmed DNA/AuNP-graphene back-gated field effect transistor as a biosensor for lead (II) ion detection
title_sort dna/aunp-graphene back-gated field effect transistor as a biosensor for lead (ii) ion detection
publisher Institute of Electrical and Electronics Engineers Inc.
publishDate 2017
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039949293&doi=10.1109%2fRSM.2017.8069165&partnerID=40&md5=a1de14776cf046e054ee2959aa3d18f3
http://eprints.utp.edu.my/19991/
_version_ 1741196298019667968
score 11.62408

Similar Items