Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology

Digital microfluidics is an emerging class of lab-on-a-chip system. Reliability is a critical performance parameter as these biochips are employed in various safety-critical biomedical applications. With the introduction of highly scalable, reconfigurable and field programmable Micro-Electrode-Dot-A...

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Main Authors: Shukla, V., Hussin, F.A., Hamid, N.H., Ali, N.B.Z., Chakrabarty, K.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.19343 /
Published: Springer New York LLC 2017
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026739994&doi=10.1007%2fs10836-017-5678-5&partnerID=40&md5=02cffd7873219dac53827178d0cdfc47
http://eprints.utp.edu.my/19343/
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spelling utp-eprints.193432018-04-20T00:19:23Z Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology Shukla, V. Hussin, F.A. Hamid, N.H. Ali, N.B.Z. Chakrabarty, K. Digital microfluidics is an emerging class of lab-on-a-chip system. Reliability is a critical performance parameter as these biochips are employed in various safety-critical biomedical applications. With the introduction of highly scalable, reconfigurable and field programmable Micro-Electrode-Dot-Array (MEDA) architecture, the limitation of conventional DMFBs in varying the droplet size/volume in fine grain manner has been resolved. However, the MEDA-based biochips must be adequately tested upon fabrication to guarantee the correctness of bioassays. In this work, an offline testing approach based on Oscillation-Based Testing (OBT) methodology is presented for MEDA-based digital microfluidic biochips. Various simulations were performed for droplet-electrode short fault model involving single and multiple micro-electrodes. Furthermore, the loss of droplet volume due to the presence of defect was analyzed using COMSOL Multiphysics. The simulation results based on PSpice and COMSOL show that the proposed approach is effective for detecting defects in MEDA-based biochips. © 2017, Springer Science+Business Media, LLC. Springer New York LLC 2017 Article PeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026739994&doi=10.1007%2fs10836-017-5678-5&partnerID=40&md5=02cffd7873219dac53827178d0cdfc47 Shukla, V. and Hussin, F.A. and Hamid, N.H. and Ali, N.B.Z. and Chakrabarty, K. (2017) Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology. Journal of Electronic Testing: Theory and Applications (JETTA), 33 (5). pp. 621-635. http://eprints.utp.edu.my/19343/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Digital microfluidics is an emerging class of lab-on-a-chip system. Reliability is a critical performance parameter as these biochips are employed in various safety-critical biomedical applications. With the introduction of highly scalable, reconfigurable and field programmable Micro-Electrode-Dot-Array (MEDA) architecture, the limitation of conventional DMFBs in varying the droplet size/volume in fine grain manner has been resolved. However, the MEDA-based biochips must be adequately tested upon fabrication to guarantee the correctness of bioassays. In this work, an offline testing approach based on Oscillation-Based Testing (OBT) methodology is presented for MEDA-based digital microfluidic biochips. Various simulations were performed for droplet-electrode short fault model involving single and multiple micro-electrodes. Furthermore, the loss of droplet volume due to the presence of defect was analyzed using COMSOL Multiphysics. The simulation results based on PSpice and COMSOL show that the proposed approach is effective for detecting defects in MEDA-based biochips. © 2017, Springer Science+Business Media, LLC.
format Article
author Shukla, V.
Hussin, F.A.
Hamid, N.H.
Ali, N.B.Z.
Chakrabarty, K.
spellingShingle Shukla, V.
Hussin, F.A.
Hamid, N.H.
Ali, N.B.Z.
Chakrabarty, K.
Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology
author_sort Shukla, V.
title Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology
title_short Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology
title_full Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology
title_fullStr Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology
title_full_unstemmed Offline Error Detection in MEDA-Based Digital Microfluidic Biochips Using Oscillation-Based Testing Methodology
title_sort offline error detection in meda-based digital microfluidic biochips using oscillation-based testing methodology
publisher Springer New York LLC
publishDate 2017
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026739994&doi=10.1007%2fs10836-017-5678-5&partnerID=40&md5=02cffd7873219dac53827178d0cdfc47
http://eprints.utp.edu.my/19343/
_version_ 1741196191534678016
score 11.62408

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