Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups

Purpose: To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between non-habitual and habitual groups due to caffeine intake. Method: This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 year...

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Main Authors: Ismail, A., Bhatti, M.S., Faye, I., Lu, C.K., Laude, A., Tang, T.B.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.20851 /
Published: Springer Verlag 2018
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048041837&doi=10.1007%2fs00417-018-4030-9&partnerID=40&md5=1ffa58ed24d03e9498a5ebcb8fec2559
http://eprints.utp.edu.my/20851/
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spelling utp-eprints.208512019-02-26T02:32:29Z Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups Ismail, A. Bhatti, M.S. Faye, I. Lu, C.K. Laude, A. Tang, T.B. Purpose: To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between non-habitual and habitual groups due to caffeine intake. Method: This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall, each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant. Result: There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the non-habitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake. Conclusion: The experiment results demonstrated caffeine does modulate OBF significantly and response differently in non-habitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups. © 2018 Springer-Verlag GmbH Germany, part of Springer Nature Springer Verlag 2018 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048041837&doi=10.1007%2fs00417-018-4030-9&partnerID=40&md5=1ffa58ed24d03e9498a5ebcb8fec2559 Ismail, A. and Bhatti, M.S. and Faye, I. and Lu, C.K. and Laude, A. and Tang, T.B. (2018) Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups. Graefe's Archive for Clinical and Experimental Ophthalmology . pp. 1-11. http://eprints.utp.edu.my/20851/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Purpose: To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between non-habitual and habitual groups due to caffeine intake. Method: This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall, each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant. Result: There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the non-habitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake. Conclusion: The experiment results demonstrated caffeine does modulate OBF significantly and response differently in non-habitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups. © 2018 Springer-Verlag GmbH Germany, part of Springer Nature
format Article
author Ismail, A.
Bhatti, M.S.
Faye, I.
Lu, C.K.
Laude, A.
Tang, T.B.
spellingShingle Ismail, A.
Bhatti, M.S.
Faye, I.
Lu, C.K.
Laude, A.
Tang, T.B.
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
author_sort Ismail, A.
title Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
title_short Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
title_full Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
title_fullStr Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
title_full_unstemmed Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
title_sort pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
publisher Springer Verlag
publishDate 2018
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048041837&doi=10.1007%2fs00417-018-4030-9&partnerID=40&md5=1ffa58ed24d03e9498a5ebcb8fec2559
http://eprints.utp.edu.my/20851/
_version_ 1741196406161408000
score 11.62408

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