Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users

Ethnopharmacological relevance: Mitragyna speciosa (Korth.) also known as kratom, is a native medicinal plant of Southeast Asia with opioid-like effects. Kratom tea/juice have been traditionally used as a folk remedy and for controlling opiate withdrawal in Malaysia. Long-term opioid use is associat...

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Main Authors: Singh, D., Murugaiyah, V., Hamid, S.B.S., Kasinather, V., Chan, M.S.A., Ho, E.T.W., Grundmann, O., Chear, N.J.Y., Mansor, S.M.
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Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.21453 /
Published: Elsevier Ireland Ltd 2018
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045758004&doi=10.1016%2fj.jep.2018.04.005&partnerID=40&md5=c77802ce43bbe5334f3b4612657c061e
http://eprints.utp.edu.my/21453/
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spelling utp-eprints.214532018-09-25T06:33:16Z Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users Singh, D. Murugaiyah, V. Hamid, S.B.S. Kasinather, V. Chan, M.S.A. Ho, E.T.W. Grundmann, O. Chear, N.J.Y. Mansor, S.M. Ethnopharmacological relevance: Mitragyna speciosa (Korth.) also known as kratom, is a native medicinal plant of Southeast Asia with opioid-like effects. Kratom tea/juice have been traditionally used as a folk remedy and for controlling opiate withdrawal in Malaysia. Long-term opioid use is associated with depletion in testosterone levels. Aim of the study: Since kratom is reported to deform sperm morphology and reduce sperm motility, we aimed to clinically investigate the testosterone levels following long-term kratom tea/juice use in regular kratom users. Methods: A total of 19 regular kratom users were recruited for this cross-sectional study. A full-blood test was conducted including determination of testosterone level, follicle stimulating hormone (FSH) and luteinizing hormone (LH) profile, as well as hematological and biochemical parameters of participants. Results: We found long-term kratom tea/juice consumption with a daily mitragynine dose of 76.23�94.15 mg did not impair testosterone levels, or gonadotrophins, hematological and biochemical parameters in regular kratom users. Conclusion: Regular kratom tea/juice consumption over prolonged periods (>2 years) was not associated with testosterone impairing effects in humans. © 2018 Elsevier B.V. Elsevier Ireland Ltd 2018 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045758004&doi=10.1016%2fj.jep.2018.04.005&partnerID=40&md5=c77802ce43bbe5334f3b4612657c061e Singh, D. and Murugaiyah, V. and Hamid, S.B.S. and Kasinather, V. and Chan, M.S.A. and Ho, E.T.W. and Grundmann, O. and Chear, N.J.Y. and Mansor, S.M. (2018) Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users. Journal of Ethnopharmacology, 221 . pp. 30-36. http://eprints.utp.edu.my/21453/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Ethnopharmacological relevance: Mitragyna speciosa (Korth.) also known as kratom, is a native medicinal plant of Southeast Asia with opioid-like effects. Kratom tea/juice have been traditionally used as a folk remedy and for controlling opiate withdrawal in Malaysia. Long-term opioid use is associated with depletion in testosterone levels. Aim of the study: Since kratom is reported to deform sperm morphology and reduce sperm motility, we aimed to clinically investigate the testosterone levels following long-term kratom tea/juice use in regular kratom users. Methods: A total of 19 regular kratom users were recruited for this cross-sectional study. A full-blood test was conducted including determination of testosterone level, follicle stimulating hormone (FSH) and luteinizing hormone (LH) profile, as well as hematological and biochemical parameters of participants. Results: We found long-term kratom tea/juice consumption with a daily mitragynine dose of 76.23�94.15 mg did not impair testosterone levels, or gonadotrophins, hematological and biochemical parameters in regular kratom users. Conclusion: Regular kratom tea/juice consumption over prolonged periods (>2 years) was not associated with testosterone impairing effects in humans. © 2018 Elsevier B.V.
format Article
author Singh, D.
Murugaiyah, V.
Hamid, S.B.S.
Kasinather, V.
Chan, M.S.A.
Ho, E.T.W.
Grundmann, O.
Chear, N.J.Y.
Mansor, S.M.
spellingShingle Singh, D.
Murugaiyah, V.
Hamid, S.B.S.
Kasinather, V.
Chan, M.S.A.
Ho, E.T.W.
Grundmann, O.
Chear, N.J.Y.
Mansor, S.M.
Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users
author_sort Singh, D.
title Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users
title_short Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users
title_full Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users
title_fullStr Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users
title_full_unstemmed Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users
title_sort assessment of gonadotropins and testosterone hormone levels in regular mitragyna speciosa (korth.) users
publisher Elsevier Ireland Ltd
publishDate 2018
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045758004&doi=10.1016%2fj.jep.2018.04.005&partnerID=40&md5=c77802ce43bbe5334f3b4612657c061e
http://eprints.utp.edu.my/21453/
_version_ 1741196462077771776
score 11.62408

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