Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen

Garcinia atroviridis Griff. ex T. Anders. is used as a medication agent in folkloric medicine. The present study was to examine the chemical composition of the stem bark and leaf of G. atroviridis as well as their cytotoxic effects against MCF-7 cells. The constituents obtained by hydrodistillation...

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Main Authors: Tan, W.-N., Lim, J.-Q., Afiqah, F., Nik Mohamed Kamal, N.N.S., Abdul Aziz, F.A., Tong, W.-Y., Leong, C.-R., Lim, J.-W.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.21634 /
Published: Taylor and Francis Ltd. 2018
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026899454&doi=10.1080%2f14786419.2017.1361951&partnerID=40&md5=cdb2baa43b08f42921afc5ac36241547
http://eprints.utp.edu.my/21634/
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spelling utp-eprints.216342018-08-01T02:56:08Z Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen Tan, W.-N. Lim, J.-Q. Afiqah, F. Nik Mohamed Kamal, N.N.S. Abdul Aziz, F.A. Tong, W.-Y. Leong, C.-R. Lim, J.-W. Garcinia atroviridis Griff. ex T. Anders. is used as a medication agent in folkloric medicine. The present study was to examine the chemical composition of the stem bark and leaf of G. atroviridis as well as their cytotoxic effects against MCF-7 cells. The constituents obtained by hydrodistillation were identified using GC-MS. The stem bark oil (EO-SB) composed mainly the palmitoleic acid (51.9) and palmitic acid (21.9), while the leaf oil (EO-L) was dominated by (E)-β-farnesene (58.5) and β-caryophyllene (16.9). Treatment of MCF-7 cells using EO-L (100 μg/mL) caused more than 50 cell death while EO-SB did not induce cytotoxic effect. EO-L has stimulated the growth of BEAS-2B normal cells, but not in MCF-7 cancerous cells. The IC50 of EO-L in MCF-7 and BEAS-2B cells were 71 and 95 μg/mL, respectively. A combination treatment of EO-L and tamoxifen induced more cell death than the treatment with drug alone at lower doses. © 2017 Informa UK Limited, trading as Taylor & Francis Group. Taylor and Francis Ltd. 2018 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026899454&doi=10.1080%2f14786419.2017.1361951&partnerID=40&md5=cdb2baa43b08f42921afc5ac36241547 Tan, W.-N. and Lim, J.-Q. and Afiqah, F. and Nik Mohamed Kamal, N.N.S. and Abdul Aziz, F.A. and Tong, W.-Y. and Leong, C.-R. and Lim, J.-W. (2018) Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen. Natural Product Research, 32 (7). pp. 854-858. http://eprints.utp.edu.my/21634/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Garcinia atroviridis Griff. ex T. Anders. is used as a medication agent in folkloric medicine. The present study was to examine the chemical composition of the stem bark and leaf of G. atroviridis as well as their cytotoxic effects against MCF-7 cells. The constituents obtained by hydrodistillation were identified using GC-MS. The stem bark oil (EO-SB) composed mainly the palmitoleic acid (51.9) and palmitic acid (21.9), while the leaf oil (EO-L) was dominated by (E)-β-farnesene (58.5) and β-caryophyllene (16.9). Treatment of MCF-7 cells using EO-L (100 μg/mL) caused more than 50 cell death while EO-SB did not induce cytotoxic effect. EO-L has stimulated the growth of BEAS-2B normal cells, but not in MCF-7 cancerous cells. The IC50 of EO-L in MCF-7 and BEAS-2B cells were 71 and 95 μg/mL, respectively. A combination treatment of EO-L and tamoxifen induced more cell death than the treatment with drug alone at lower doses. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
format Article
author Tan, W.-N.
Lim, J.-Q.
Afiqah, F.
Nik Mohamed Kamal, N.N.S.
Abdul Aziz, F.A.
Tong, W.-Y.
Leong, C.-R.
Lim, J.-W.
spellingShingle Tan, W.-N.
Lim, J.-Q.
Afiqah, F.
Nik Mohamed Kamal, N.N.S.
Abdul Aziz, F.A.
Tong, W.-Y.
Leong, C.-R.
Lim, J.-W.
Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen
author_sort Tan, W.-N.
title Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen
title_short Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen
title_full Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen
title_fullStr Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen
title_full_unstemmed Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen
title_sort chemical composition and cytotoxic activity of garcinia atroviridis griff. ex t. anders. essential oils in combination with tamoxifen
publisher Taylor and Francis Ltd.
publishDate 2018
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026899454&doi=10.1080%2f14786419.2017.1361951&partnerID=40&md5=cdb2baa43b08f42921afc5ac36241547
http://eprints.utp.edu.my/21634/
_version_ 1741196491282710528
score 11.62408

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