Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity
The behavior of the inclusion behavior of guanosine (GU) with beta-cyclodextrin (β-CD) in the liquid, solid and virtual state were investigated. The absorption and fluorescence spectral were used to determine the inclusion behavior in liquid state. FT-IR, NMR, TGA, DSC, PXRD and FESEM techniques we...
| Main Authors: | Prabu, S., Samad, N.A., Ahmad, N.A., Jumbri, K., Raoov, M., Rahim, N.Y., Samikannu, K., Mohamad, S. |
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| Format: | Article |
| Institution: | Universiti Teknologi Petronas |
| Record Id / ISBN-0: | utp-eprints.29784 / |
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Elsevier Ltd
2020
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090364556&doi=10.1016%2fj.carres.2020.108138&partnerID=40&md5=fd9cf4353a742d22bed70886f9c4742d http://eprints.utp.edu.my/29784/ |
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utp-eprints.297842022-03-25T02:51:06Z Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity Prabu, S. Samad, N.A. Ahmad, N.A. Jumbri, K. Raoov, M. Rahim, N.Y. Samikannu, K. Mohamad, S. The behavior of the inclusion behavior of guanosine (GU) with beta-cyclodextrin (β-CD) in the liquid, solid and virtual state were investigated. The absorption and fluorescence spectral were used to determine the inclusion behavior in liquid state. FT-IR, NMR, TGA, DSC, PXRD and FESEM techniques were used to investigate the inclusion behavior in solid-state, meanwhile the virtual state studies are done by molecular docking. The solid inclusion complex (GU: β-CD) was prepared by using the co-precipitation method. The binding constant (K) of (GU: β-CD) was calculated by using Benesi-Hildebrand. Besides that, the 1:1 stoichiometric ratio of inclusion complex was confirmed by using the Benesi-Hildebrand plot and Job's plot of continuous variation method. The most preferable model of GU: β-CD that suggested via molecular docking studies was in good agreement with experimental results. The inclusion complex of GU: β-CD exerted its toxicity effects towards HepG2 cell lines based on the reduced number of cell viability and lowest IC50 value compared to the GU and β-CD viability. © 2020 Elsevier Ltd Elsevier Ltd 2020 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090364556&doi=10.1016%2fj.carres.2020.108138&partnerID=40&md5=fd9cf4353a742d22bed70886f9c4742d Prabu, S. and Samad, N.A. and Ahmad, N.A. and Jumbri, K. and Raoov, M. and Rahim, N.Y. and Samikannu, K. and Mohamad, S. (2020) Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity. Carbohydrate Research, 497 . http://eprints.utp.edu.my/29784/ |
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Universiti Teknologi Petronas |
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UTP Institutional Repository |
| description |
The behavior of the inclusion behavior of guanosine (GU) with beta-cyclodextrin (β-CD) in the liquid, solid and virtual state were investigated. The absorption and fluorescence spectral were used to determine the inclusion behavior in liquid state. FT-IR, NMR, TGA, DSC, PXRD and FESEM techniques were used to investigate the inclusion behavior in solid-state, meanwhile the virtual state studies are done by molecular docking. The solid inclusion complex (GU: β-CD) was prepared by using the co-precipitation method. The binding constant (K) of (GU: β-CD) was calculated by using Benesi-Hildebrand. Besides that, the 1:1 stoichiometric ratio of inclusion complex was confirmed by using the Benesi-Hildebrand plot and Job's plot of continuous variation method. The most preferable model of GU: β-CD that suggested via molecular docking studies was in good agreement with experimental results. The inclusion complex of GU: β-CD exerted its toxicity effects towards HepG2 cell lines based on the reduced number of cell viability and lowest IC50 value compared to the GU and β-CD viability. © 2020 Elsevier Ltd |
| format |
Article |
| author |
Prabu, S. Samad, N.A. Ahmad, N.A. Jumbri, K. Raoov, M. Rahim, N.Y. Samikannu, K. Mohamad, S. |
| spellingShingle |
Prabu, S. Samad, N.A. Ahmad, N.A. Jumbri, K. Raoov, M. Rahim, N.Y. Samikannu, K. Mohamad, S. Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity |
| author_sort |
Prabu, S. |
| title |
Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity |
| title_short |
Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity |
| title_full |
Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity |
| title_fullStr |
Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity |
| title_full_unstemmed |
Studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity |
| title_sort |
studies on the supramolecular complex of a guanosine with beta-cyclodextrin and evaluation of its anti-proliferative activity |
| publisher |
Elsevier Ltd |
| publishDate |
2020 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090364556&doi=10.1016%2fj.carres.2020.108138&partnerID=40&md5=fd9cf4353a742d22bed70886f9c4742d http://eprints.utp.edu.my/29784/ |
| _version_ |
1741197299095175168 |
| score |
11.62408 |