Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol

Inclusion of a large amount of deep eutectic solvent (DES) in a microemulsion (ME) may enhance transdermal permeation of resveratrol (RSV) due to its high solubility in DES of the inner phase. We prepared MEs with different DES loading and surfactant composition, and investigated the entrapment amou...

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Main Authors: Sakuragi, M., Yano, R., Hasnol, S.B.M., Kusakabe, K.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.30012 /
Published: IOP Publishing Ltd 2020
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091657124&doi=10.35848%2f1347-4065%2fabaa94&partnerID=40&md5=0c91b04d200aa74cd8469e2bfbecd12f
http://eprints.utp.edu.my/30012/
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spelling utp-eprints.300122022-03-25T03:17:56Z Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol Sakuragi, M. Yano, R. Hasnol, S.B.M. Kusakabe, K. Inclusion of a large amount of deep eutectic solvent (DES) in a microemulsion (ME) may enhance transdermal permeation of resveratrol (RSV) due to its high solubility in DES of the inner phase. We prepared MEs with different DES loading and surfactant composition, and investigated the entrapment amount of RSV, the structures of the MEs, and their skin penetration amount. We found that MEs at Tween-80/Span-20 = 4/1 (wt/wt) (T4S1) were able to contain the largest amount of DES in the inner phase. The structural characterization results showed that T4S1-MEs containing more than 20 wt DES and less than 10 wt DES formed a vesicle containing DES in the membrane of surfactants and a spherical micelle containing DES in the inner phase, respectively. The vesicles containing more than 20 wt DES were able to trap a larger amount of RSV and deliver more RSV through the stratum corneum compared to the spherical micelles containing less than 10 wt DES. © 2020 The Japan Society of Applied Physics. IOP Publishing Ltd 2020 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091657124&doi=10.35848%2f1347-4065%2fabaa94&partnerID=40&md5=0c91b04d200aa74cd8469e2bfbecd12f Sakuragi, M. and Yano, R. and Hasnol, S.B.M. and Kusakabe, K. (2020) Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol. Japanese Journal of Applied Physics, 59 (9). http://eprints.utp.edu.my/30012/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Inclusion of a large amount of deep eutectic solvent (DES) in a microemulsion (ME) may enhance transdermal permeation of resveratrol (RSV) due to its high solubility in DES of the inner phase. We prepared MEs with different DES loading and surfactant composition, and investigated the entrapment amount of RSV, the structures of the MEs, and their skin penetration amount. We found that MEs at Tween-80/Span-20 = 4/1 (wt/wt) (T4S1) were able to contain the largest amount of DES in the inner phase. The structural characterization results showed that T4S1-MEs containing more than 20 wt DES and less than 10 wt DES formed a vesicle containing DES in the membrane of surfactants and a spherical micelle containing DES in the inner phase, respectively. The vesicles containing more than 20 wt DES were able to trap a larger amount of RSV and deliver more RSV through the stratum corneum compared to the spherical micelles containing less than 10 wt DES. © 2020 The Japan Society of Applied Physics.
format Article
author Sakuragi, M.
Yano, R.
Hasnol, S.B.M.
Kusakabe, K.
spellingShingle Sakuragi, M.
Yano, R.
Hasnol, S.B.M.
Kusakabe, K.
Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol
author_sort Sakuragi, M.
title Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol
title_short Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol
title_full Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol
title_fullStr Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol
title_full_unstemmed Evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol
title_sort evaluation of microemulsions containing a large amount of a deep eutectic solvent as a potential transdermal carrier of resveratrol
publisher IOP Publishing Ltd
publishDate 2020
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091657124&doi=10.35848%2f1347-4065%2fabaa94&partnerID=40&md5=0c91b04d200aa74cd8469e2bfbecd12f
http://eprints.utp.edu.my/30012/
_version_ 1741197335835181056
score 11.62408

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