Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin

Liquid-liquid extraction is one of the analytical methods that is commonly used for separation of various analytes. Nevertheless, the method is not capable to operate with hydrophobic medical drugs, particularly metformin where the drug is essentially used as an antidiabetic (Type II diabetes). Prel...

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Main Authors: Jajuli, M.N., Hussin, M.H., Rahim, A.A., Saad, B., Hébrant, M., Herzog, G.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.30225 /
Published: Penerbit Universiti Sains Malaysia 2019
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083401695&doi=10.21315%2fJPS2019.30.S2.13&partnerID=40&md5=00803147857046f677e563f8a39b7a62
http://eprints.utp.edu.my/30225/
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spelling utp-eprints.302252022-03-25T06:38:47Z Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin Jajuli, M.N. Hussin, M.H. Rahim, A.A. Saad, B. Hébrant, M. Herzog, G. Liquid-liquid extraction is one of the analytical methods that is commonly used for separation of various analytes. Nevertheless, the method is not capable to operate with hydrophobic medical drugs, particularly metformin where the drug is essentially used as an antidiabetic (Type II diabetes). Preliminary studies on extractions of metformin, phenyl biguanide and propranolol were accomplished using electrochemically modulated liquid-liquid extraction (EMLLE) method as a sample preparation method. The principle is based on application of electrically driving force to transfer the desired ions across the interface between two immiscible electrolyte solutions (ITIES). The extraction of three cationic drugs from artificial urine to 1, 2-dichoroethane, is controlled by external polarisation. By using ITIES cells, all of the drugs are found to transfer within the available potential window. The application of different galvani potential differences enables the selective extraction of drugs. Potential window of artificial urine shorter than lithium chloride as aqueous phase. Nevertheless, for both cases, the first drug to be extracted is propranolol which is the most hydrophobic drug and hence a lower potential is needed to transfer this cationic molecule across the interface as followed by phenylbiguanide and metformin. © Penerbit Universiti Sains Malaysia, 2019. Penerbit Universiti Sains Malaysia 2019 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083401695&doi=10.21315%2fJPS2019.30.S2.13&partnerID=40&md5=00803147857046f677e563f8a39b7a62 Jajuli, M.N. and Hussin, M.H. and Rahim, A.A. and Saad, B. and Hébrant, M. and Herzog, G. (2019) Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin. Journal of Physical Science, 30 . pp. 153-166. http://eprints.utp.edu.my/30225/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Liquid-liquid extraction is one of the analytical methods that is commonly used for separation of various analytes. Nevertheless, the method is not capable to operate with hydrophobic medical drugs, particularly metformin where the drug is essentially used as an antidiabetic (Type II diabetes). Preliminary studies on extractions of metformin, phenyl biguanide and propranolol were accomplished using electrochemically modulated liquid-liquid extraction (EMLLE) method as a sample preparation method. The principle is based on application of electrically driving force to transfer the desired ions across the interface between two immiscible electrolyte solutions (ITIES). The extraction of three cationic drugs from artificial urine to 1, 2-dichoroethane, is controlled by external polarisation. By using ITIES cells, all of the drugs are found to transfer within the available potential window. The application of different galvani potential differences enables the selective extraction of drugs. Potential window of artificial urine shorter than lithium chloride as aqueous phase. Nevertheless, for both cases, the first drug to be extracted is propranolol which is the most hydrophobic drug and hence a lower potential is needed to transfer this cationic molecule across the interface as followed by phenylbiguanide and metformin. © Penerbit Universiti Sains Malaysia, 2019.
format Article
author Jajuli, M.N.
Hussin, M.H.
Rahim, A.A.
Saad, B.
Hébrant, M.
Herzog, G.
spellingShingle Jajuli, M.N.
Hussin, M.H.
Rahim, A.A.
Saad, B.
Hébrant, M.
Herzog, G.
Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin
author_sort Jajuli, M.N.
title Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin
title_short Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin
title_full Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin
title_fullStr Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin
title_full_unstemmed Preliminary assays on electrochemically modulated liquid-liquid extraction of metformin
title_sort preliminary assays on electrochemically modulated liquid-liquid extraction of metformin
publisher Penerbit Universiti Sains Malaysia
publishDate 2019
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083401695&doi=10.21315%2fJPS2019.30.S2.13&partnerID=40&md5=00803147857046f677e563f8a39b7a62
http://eprints.utp.edu.my/30225/
_version_ 1741197370250493952
score 11.62408

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