New cholinesterase inhibitory constituents from Lonicera quinquelocularis

A phytochemical investigation on the ethyl acetate soluble fraction of Lonicera quinquelocularis (whole plant) led to the first time isolation of one new phthalate; bis(7-acetoxy-2-ethyl-5-methylheptyl) phthalate (3) and two new benzoates; neopentyl-4- ethoxy-3, 5-bis (3-methyl-2-butenyl benzoate (4...

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Main Authors: Khan, D., Khan, H.U., Khan, F., Khan, S., Badshah, S., Khan, A.S., Samad, A., Ali, F., Khan, I., Muhammad, N.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.31280 /
Published: Public Library of Science 2014
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899660742&doi=10.1371%2fjournal.pone.0094952&partnerID=40&md5=ed42fe994686eb2503918f56166c5c5d
http://eprints.utp.edu.my/31280/
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spelling utp-eprints.312802022-03-25T09:05:06Z New cholinesterase inhibitory constituents from Lonicera quinquelocularis Khan, D. Khan, H.U. Khan, F. Khan, S. Badshah, S. Khan, A.S. Samad, A. Ali, F. Khan, I. Muhammad, N. A phytochemical investigation on the ethyl acetate soluble fraction of Lonicera quinquelocularis (whole plant) led to the first time isolation of one new phthalate; bis(7-acetoxy-2-ethyl-5-methylheptyl) phthalate (3) and two new benzoates; neopentyl-4- ethoxy-3, 5-bis (3-methyl-2-butenyl benzoate (4) and neopentyl-4-hydroxy-3, 5-bis (3-methyl-2-butenyl benzoate (5) along with two known compounds bis (2-ethylhexyl phthalate (1) and dioctyl phthalate (2). Their structures were established on the basis of spectroscopic analysis and by comparison with available data in the literature. All the compounds (1-5) were tested for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities in dose dependent manner. The IC50 (50 inhibitory effect) values of compounds 3 and 5 against AChE were 1.65 and 3.43 μM while the values obtained against BChE were 5.98 and 9.84 μM respectively. Compounds 2 and 4 showed weak inhibition profile. © 2014 Khan et al. Public Library of Science 2014 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899660742&doi=10.1371%2fjournal.pone.0094952&partnerID=40&md5=ed42fe994686eb2503918f56166c5c5d Khan, D. and Khan, H.U. and Khan, F. and Khan, S. and Badshah, S. and Khan, A.S. and Samad, A. and Ali, F. and Khan, I. and Muhammad, N. (2014) New cholinesterase inhibitory constituents from Lonicera quinquelocularis. PLoS ONE, 9 (4). http://eprints.utp.edu.my/31280/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description A phytochemical investigation on the ethyl acetate soluble fraction of Lonicera quinquelocularis (whole plant) led to the first time isolation of one new phthalate; bis(7-acetoxy-2-ethyl-5-methylheptyl) phthalate (3) and two new benzoates; neopentyl-4- ethoxy-3, 5-bis (3-methyl-2-butenyl benzoate (4) and neopentyl-4-hydroxy-3, 5-bis (3-methyl-2-butenyl benzoate (5) along with two known compounds bis (2-ethylhexyl phthalate (1) and dioctyl phthalate (2). Their structures were established on the basis of spectroscopic analysis and by comparison with available data in the literature. All the compounds (1-5) were tested for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities in dose dependent manner. The IC50 (50 inhibitory effect) values of compounds 3 and 5 against AChE were 1.65 and 3.43 μM while the values obtained against BChE were 5.98 and 9.84 μM respectively. Compounds 2 and 4 showed weak inhibition profile. © 2014 Khan et al.
format Article
author Khan, D.
Khan, H.U.
Khan, F.
Khan, S.
Badshah, S.
Khan, A.S.
Samad, A.
Ali, F.
Khan, I.
Muhammad, N.
spellingShingle Khan, D.
Khan, H.U.
Khan, F.
Khan, S.
Badshah, S.
Khan, A.S.
Samad, A.
Ali, F.
Khan, I.
Muhammad, N.
New cholinesterase inhibitory constituents from Lonicera quinquelocularis
author_sort Khan, D.
title New cholinesterase inhibitory constituents from Lonicera quinquelocularis
title_short New cholinesterase inhibitory constituents from Lonicera quinquelocularis
title_full New cholinesterase inhibitory constituents from Lonicera quinquelocularis
title_fullStr New cholinesterase inhibitory constituents from Lonicera quinquelocularis
title_full_unstemmed New cholinesterase inhibitory constituents from Lonicera quinquelocularis
title_sort new cholinesterase inhibitory constituents from lonicera quinquelocularis
publisher Public Library of Science
publishDate 2014
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899660742&doi=10.1371%2fjournal.pone.0094952&partnerID=40&md5=ed42fe994686eb2503918f56166c5c5d
http://eprints.utp.edu.my/31280/
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score 11.62408

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