Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection

Ochratoxin A (OTA) has harmful effects to human and animal health; therefore, sensitive and selective detection of OTA is highly demanded. Herein, an ultrasensitive electrochemical aptasensor electrode comprising electrospun MXene/polyvinylidene fluoride (Ti3C2Tx/PVDF) nanofiber composite is present...

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Main Authors: Al-Dhahebi, A.M., Jose, R., Mustapha, M., Saheed, M.S.M.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.33313 /
Published: Elsevier Ltd 2022
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130371663&doi=10.1016%2fj.foodchem.2022.133105&partnerID=40&md5=86fc5c616235a8266264b126078d8dda
http://eprints.utp.edu.my/33313/
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spelling utp-eprints.333132022-07-26T06:40:16Z Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection Al-Dhahebi, A.M. Jose, R. Mustapha, M. Saheed, M.S.M. Ochratoxin A (OTA) has harmful effects to human and animal health; therefore, sensitive and selective detection of OTA is highly demanded. Herein, an ultrasensitive electrochemical aptasensor electrode comprising electrospun MXene/polyvinylidene fluoride (Ti3C2Tx/PVDF) nanofiber composite is presented. Addition of Ti3C2Tx up to 13 effectively increased the fiber diameter and lowered the β-phase of PVDF nanofibers, consequently lowering the charge transfer resistance. The nanofiber composite is then coated on the screen-printed carbon electrode to chemically functionalized with saline and aldehyde groups for efficient aptamer loading. The optimized aptasensor demonstrated sensitive detection of OTA over the dynamic concentration range from 1 fg mL�1 to 1 ng mL�1 with a limit of detection of 2.15 fg mL�1 and quantification limit of 6.52 fg mL�1, with high selectivity. The aptasensor could detect the OTA at femtogram per milliliter concentration in grape juice samples, demonstrating its enormous potential for OTA detection in food industry. © 2022 Elsevier Ltd Elsevier Ltd 2022 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130371663&doi=10.1016%2fj.foodchem.2022.133105&partnerID=40&md5=86fc5c616235a8266264b126078d8dda Al-Dhahebi, A.M. and Jose, R. and Mustapha, M. and Saheed, M.S.M. (2022) Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection. Food Chemistry, 390 . http://eprints.utp.edu.my/33313/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Ochratoxin A (OTA) has harmful effects to human and animal health; therefore, sensitive and selective detection of OTA is highly demanded. Herein, an ultrasensitive electrochemical aptasensor electrode comprising electrospun MXene/polyvinylidene fluoride (Ti3C2Tx/PVDF) nanofiber composite is presented. Addition of Ti3C2Tx up to 13 effectively increased the fiber diameter and lowered the β-phase of PVDF nanofibers, consequently lowering the charge transfer resistance. The nanofiber composite is then coated on the screen-printed carbon electrode to chemically functionalized with saline and aldehyde groups for efficient aptamer loading. The optimized aptasensor demonstrated sensitive detection of OTA over the dynamic concentration range from 1 fg mL�1 to 1 ng mL�1 with a limit of detection of 2.15 fg mL�1 and quantification limit of 6.52 fg mL�1, with high selectivity. The aptasensor could detect the OTA at femtogram per milliliter concentration in grape juice samples, demonstrating its enormous potential for OTA detection in food industry. © 2022 Elsevier Ltd
format Article
author Al-Dhahebi, A.M.
Jose, R.
Mustapha, M.
Saheed, M.S.M.
spellingShingle Al-Dhahebi, A.M.
Jose, R.
Mustapha, M.
Saheed, M.S.M.
Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection
author_sort Al-Dhahebi, A.M.
title Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection
title_short Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection
title_full Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection
title_fullStr Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection
title_full_unstemmed Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection
title_sort ultrasensitive aptasensor using electrospun mxene/polyvinylidene fluoride nanofiber composite for ochratoxin a detection
publisher Elsevier Ltd
publishDate 2022
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130371663&doi=10.1016%2fj.foodchem.2022.133105&partnerID=40&md5=86fc5c616235a8266264b126078d8dda
http://eprints.utp.edu.my/33313/
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score 11.62408

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