Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery

Ionic liquids (ILs) have attracted growing interest as designer solvents/materials for exploring unrealized functions in many areas of research including drug formulations and delivery owing to their inherent tunable physicochemical and biological properties. The use of ILs in the pharmaceutical ind...

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Main Authors: Ali, M.K., Moshikur, R.M., Goto, M., Moniruzzaman, M.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.33399 /
Published: Springer 2022
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133291375&doi=10.1007%2fs11095-022-03322-x&partnerID=40&md5=8a8a0bccb91dc80d5ca932f5b199598f
http://eprints.utp.edu.my/33399/
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spelling utp-eprints.333992022-07-26T08:46:10Z Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery Ali, M.K. Moshikur, R.M. Goto, M. Moniruzzaman, M. Ionic liquids (ILs) have attracted growing interest as designer solvents/materials for exploring unrealized functions in many areas of research including drug formulations and delivery owing to their inherent tunable physicochemical and biological properties. The use of ILs in the pharmaceutical industry can address challenges related to the use of conventional organic solvent-based chemical permeation enhancers. Their tunability in forming ion pairs with a diverse range of ions enables the task-specific optimization of ILs at the molecular level. In particular, ILs comprising second- and third-generation cations and anions have been extensively used to design biocompatible drug delivery systems to address the challenges related to conventional topical and transdermal drug delivery, including limited permeability, high cytotoxicity, and skin irritation. This review highlights the progress in IL-related research with particular emphasis on the very recent conceptual developments in transdermal drug delivery. Technological advancement and approaches for the formation of IL-based topical and transdermal delivery systems, as well as their promising application in drug delivery, are also discussed. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. Springer 2022 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133291375&doi=10.1007%2fs11095-022-03322-x&partnerID=40&md5=8a8a0bccb91dc80d5ca932f5b199598f Ali, M.K. and Moshikur, R.M. and Goto, M. and Moniruzzaman, M. (2022) Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery. Pharmaceutical Research . http://eprints.utp.edu.my/33399/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Ionic liquids (ILs) have attracted growing interest as designer solvents/materials for exploring unrealized functions in many areas of research including drug formulations and delivery owing to their inherent tunable physicochemical and biological properties. The use of ILs in the pharmaceutical industry can address challenges related to the use of conventional organic solvent-based chemical permeation enhancers. Their tunability in forming ion pairs with a diverse range of ions enables the task-specific optimization of ILs at the molecular level. In particular, ILs comprising second- and third-generation cations and anions have been extensively used to design biocompatible drug delivery systems to address the challenges related to conventional topical and transdermal drug delivery, including limited permeability, high cytotoxicity, and skin irritation. This review highlights the progress in IL-related research with particular emphasis on the very recent conceptual developments in transdermal drug delivery. Technological advancement and approaches for the formation of IL-based topical and transdermal delivery systems, as well as their promising application in drug delivery, are also discussed. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
format Article
author Ali, M.K.
Moshikur, R.M.
Goto, M.
Moniruzzaman, M.
spellingShingle Ali, M.K.
Moshikur, R.M.
Goto, M.
Moniruzzaman, M.
Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery
author_sort Ali, M.K.
title Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery
title_short Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery
title_full Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery
title_fullStr Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery
title_full_unstemmed Recent Developments in Ionic Liquid-Assisted Topical and Transdermal Drug Delivery
title_sort recent developments in ionic liquid-assisted topical and transdermal drug delivery
publisher Springer
publishDate 2022
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133291375&doi=10.1007%2fs11095-022-03322-x&partnerID=40&md5=8a8a0bccb91dc80d5ca932f5b199598f
http://eprints.utp.edu.my/33399/
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score 11.62408

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