Gravimetric Study of the Solubility and Dissociation of Benzoic Acid: Effect of Cosolvent and Temperature

Solubility study is an important parameter to reach desired concentration of substance especially in pharmaceutical industry. Poorly water soluble crystals may require high doses in order to achieve the required outcome for the process. Benzoic acid (C7H6O2) is widely known as an intermediate for...

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Main Author: Salem Al-Gariri, Hesham Saeed
Format: Final Year Project
Language: English
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-utpedia.22867 /
Published: Universiti Teknologi PETRONAS 2016
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Online Access: http://utpedia.utp.edu.my/22867/1/Hesham%20Saeed%20Salem%20Al-Gariri_16669.pdf
http://utpedia.utp.edu.my/22867/
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Summary: Solubility study is an important parameter to reach desired concentration of substance especially in pharmaceutical industry. Poorly water soluble crystals may require high doses in order to achieve the required outcome for the process. Benzoic acid (C7H6O2) is widely known as an intermediate for synthesis of several organic substances applied in the fields of pharmaceuticals, resins, plasticizers, dyes and cosmetics. The aqueous solubility of benzoic acid is sparingly low due to its hydrophobic characterstics which is the main issue in this study. This research aims on enhancing the solubility of benzoic acid by using different co-solvents.