Potential of Chitosan and its derivatives for controlled drug release applications � A review
Recent research on the drug delivery systems exhibited tremendous improvements for several short life drugs which disappear in few minutes in harsh conditions of the Gastrointestinal tract (GIT). After years of investigations, the current drug delivery system has been improved with new advanced mate...
| Main Authors: | Safdar, R., Omar, A.A., Arunagiri, A., Regupathi, I., Thanabalan, M. |
|---|---|
| Format: | Article |
| Institution: | Universiti Teknologi Petronas |
| Record Id / ISBN-0: | utp-eprints.22164 / |
| Published: |
2019
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059848320&doi=10.1016%2fj.jddst.2018.10.020&partnerID=40&md5=9b914cd86dcd91253d138cf6c4d3e484 http://eprints.utp.edu.my/22164/ |
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utp-eprints.221642019-02-28T05:47:02Z Potential of Chitosan and its derivatives for controlled drug release applications � A review Safdar, R. Omar, A.A. Arunagiri, A. Regupathi, I. Thanabalan, M. Recent research on the drug delivery systems exhibited tremendous improvements for several short life drugs which disappear in few minutes in harsh conditions of the Gastrointestinal tract (GIT). After years of investigations, the current drug delivery system has been improved with new advanced materials with less toxicity and better therapeutic efficiency. In this regard, new formulations consisting of drugs encapsulated with natural biodegradable copolymer, Chitosan, in the form of nanoparticles have been studied, which in turn improved the release profile of drugs. In this review, the Chitosan and its physiochemical properties, nanoparticles and their drug release mechanism and effects of modification of various drugs (anti�cancer, anti�inflammatory, anti�diabetes, anti�infectious drugs etc) with Chitosan and co�materials on their release profiles are briefly reviewed. These biodegradable polymeric nanoparticles improved the in vitro release profile of drugs and provided a way forward for further improvement of the current and conventional drug delivery systems. © 2018 Elsevier B.V. 2019 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059848320&doi=10.1016%2fj.jddst.2018.10.020&partnerID=40&md5=9b914cd86dcd91253d138cf6c4d3e484 Safdar, R. and Omar, A.A. and Arunagiri, A. and Regupathi, I. and Thanabalan, M. (2019) Potential of Chitosan and its derivatives for controlled drug release applications � A review. Journal of Drug Delivery Science and Technology, 49 . pp. 642-659. http://eprints.utp.edu.my/22164/ |
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Universiti Teknologi Petronas |
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UTP Institutional Repository |
| description |
Recent research on the drug delivery systems exhibited tremendous improvements for several short life drugs which disappear in few minutes in harsh conditions of the Gastrointestinal tract (GIT). After years of investigations, the current drug delivery system has been improved with new advanced materials with less toxicity and better therapeutic efficiency. In this regard, new formulations consisting of drugs encapsulated with natural biodegradable copolymer, Chitosan, in the form of nanoparticles have been studied, which in turn improved the release profile of drugs. In this review, the Chitosan and its physiochemical properties, nanoparticles and their drug release mechanism and effects of modification of various drugs (anti�cancer, anti�inflammatory, anti�diabetes, anti�infectious drugs etc) with Chitosan and co�materials on their release profiles are briefly reviewed. These biodegradable polymeric nanoparticles improved the in vitro release profile of drugs and provided a way forward for further improvement of the current and conventional drug delivery systems. © 2018 Elsevier B.V. |
| format |
Article |
| author |
Safdar, R. Omar, A.A. Arunagiri, A. Regupathi, I. Thanabalan, M. |
| spellingShingle |
Safdar, R. Omar, A.A. Arunagiri, A. Regupathi, I. Thanabalan, M. Potential of Chitosan and its derivatives for controlled drug release applications � A review |
| author_sort |
Safdar, R. |
| title |
Potential of Chitosan and its derivatives for controlled drug release applications � A review |
| title_short |
Potential of Chitosan and its derivatives for controlled drug release applications � A review |
| title_full |
Potential of Chitosan and its derivatives for controlled drug release applications � A review |
| title_fullStr |
Potential of Chitosan and its derivatives for controlled drug release applications � A review |
| title_full_unstemmed |
Potential of Chitosan and its derivatives for controlled drug release applications � A review |
| title_sort |
potential of chitosan and its derivatives for controlled drug release applications � a review |
| publishDate |
2019 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059848320&doi=10.1016%2fj.jddst.2018.10.020&partnerID=40&md5=9b914cd86dcd91253d138cf6c4d3e484 http://eprints.utp.edu.my/22164/ |
| _version_ |
1741196578365898752 |
| score |
11.62408 |