Valuation system connectivity is correlated with poly-drug use in young adults

Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks may give insight into the motivations behind poly-drug use. We correlated average functional connectivity of the valuation system (VS), executive control system (ECS) and...

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Main Authors: Loganathan, K., Lv, J., Cropley, V., Zalesky, A., Ho, E.T.W.
Format: Article
Institution: Universiti Teknologi Petronas
Record Id / ISBN-0: utp-eprints.29671 /
Published: Elsevier Ireland Ltd 2021
Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109778725&doi=10.1016%2fj.neures.2021.06.006&partnerID=40&md5=e0fa4b716e6e89292c36f2cf2345b246
http://eprints.utp.edu.my/29671/
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spelling utp-eprints.296712022-03-25T02:29:53Z Valuation system connectivity is correlated with poly-drug use in young adults Loganathan, K. Lv, J. Cropley, V. Zalesky, A. Ho, E.T.W. Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks may give insight into the motivations behind poly-drug use. We correlated average functional connectivity of the valuation system (VS), executive control system (ECS) and valuation-control complex (VCC) in a large population sample (n = 992) with drug use behaviour. VS connectivity is correlated with sedative use, ECS connectivity is separately correlated with hallucinogens and opiates. Network connectivity is also correlated with drug use via two-way interactions with other substances including alcohol and tobacco. These preliminary findings can contribute to our understanding of the common combinations of substance co-use and associated neural patterns. © 2021 Elsevier B.V. and Japan Neuroscience Society Elsevier Ireland Ltd 2021 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109778725&doi=10.1016%2fj.neures.2021.06.006&partnerID=40&md5=e0fa4b716e6e89292c36f2cf2345b246 Loganathan, K. and Lv, J. and Cropley, V. and Zalesky, A. and Ho, E.T.W. (2021) Valuation system connectivity is correlated with poly-drug use in young adults. Neuroscience Research, 173 . pp. 114-120. http://eprints.utp.edu.my/29671/
institution Universiti Teknologi Petronas
collection UTP Institutional Repository
description Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks may give insight into the motivations behind poly-drug use. We correlated average functional connectivity of the valuation system (VS), executive control system (ECS) and valuation-control complex (VCC) in a large population sample (n = 992) with drug use behaviour. VS connectivity is correlated with sedative use, ECS connectivity is separately correlated with hallucinogens and opiates. Network connectivity is also correlated with drug use via two-way interactions with other substances including alcohol and tobacco. These preliminary findings can contribute to our understanding of the common combinations of substance co-use and associated neural patterns. © 2021 Elsevier B.V. and Japan Neuroscience Society
format Article
author Loganathan, K.
Lv, J.
Cropley, V.
Zalesky, A.
Ho, E.T.W.
spellingShingle Loganathan, K.
Lv, J.
Cropley, V.
Zalesky, A.
Ho, E.T.W.
Valuation system connectivity is correlated with poly-drug use in young adults
author_sort Loganathan, K.
title Valuation system connectivity is correlated with poly-drug use in young adults
title_short Valuation system connectivity is correlated with poly-drug use in young adults
title_full Valuation system connectivity is correlated with poly-drug use in young adults
title_fullStr Valuation system connectivity is correlated with poly-drug use in young adults
title_full_unstemmed Valuation system connectivity is correlated with poly-drug use in young adults
title_sort valuation system connectivity is correlated with poly-drug use in young adults
publisher Elsevier Ireland Ltd
publishDate 2021
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109778725&doi=10.1016%2fj.neures.2021.06.006&partnerID=40&md5=e0fa4b716e6e89292c36f2cf2345b246
http://eprints.utp.edu.my/29671/
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score 11.62408

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